To become a successful Full Stack Developer, focus on mastering both front-end and back-end technologies. Start by learning HTML, CSS, and JavaScript for the front end, and then move on to server-side languages like Python, Java, or Node.js for the back end. Additionally, become proficient in databases, version control systems, and deployment technologies. Continuously learn and stay updated with the latest trends and technologies in Full Stack development to enhance your skills and advance your career.